Department of Radiological Sciences
Office Phone: 314-362-7318
Lab Phone: 314-747-0590
Washington University School of Medicine
Department of Radiology, Campus Box 8225, Rm 3413
4525 Scott Ave.
St. Louis, MO 63110 USA
Investigation of the bases of state changes and state transitions in the brain. These studies use combined electrophysiological measures (electroencephalography, EEG and electrocorticography, ECoG) and functional magnetic resonance imaging (fMRI) to examine changes in the network activity of the brain in the transition from wake to sleep.
The role of sleep in learning, memory and cognitive performance in normal subjects and in individuals suffering from such sleep-related problems as insomnia and sleep disordered breathing. Collaborative investigations include studies of the effect of short duration sleep bouts (nap) on both procedural and declarative memory task performance.
Analysis of electrophysiological signals recorded from the human brain, including the development of new signal processing technologies for integration of these signals with those obtained by other imaging or recording modalities.
Dr. Larson-Prior is also very interested in mentor/mentee relationships, which she considers central to success in modern research science. As a result, she attended the Teaching Survival Skills and Ethics Course in Snowmass CO in 2003 and is mentoring in the Ferring Scholars program through WUSM.
Larson-Prior, L.J., Zempel, J., Nolan, T.S., Prior, F.W., Snyder, A.Z. and Raichle, M.E. (2009) Cortical network functional connectivity is maintained in the descent to sleep. PNAS, 106:4489-4494. PMID: PMC2657465
Larson-Prior, L.J., Power, J.D., Vincent, J.L., Nolan, T.S., Coalson, R.S., Zempel, J., Snyder, A.Z., Schlaggar, B.L., Raichle, M.E., Petersen, S.E. (2011) Modulation of the brain’s functional network architecture in the transition from wake to sleep. Prog. Br. Res., 193:277-294. PMID 21854969.
Zempel, J.M., Politte, D., Kelsey, M., Verner, R., Nolan, T.S., Babajani-Feremi, A., Prior, F. Larson-Prior, L.J. (2012) Characterization of scale-free properties of human electrocorticography in awake and slow-wave sleep states. Front Neurol, 3:76 PMID 22701446
Larson-Prior, L.J., Oostenveld, R., Della Penna, S., Michalareas, G., Prior, F., Babajani-Feremi, A., Schoffelen, J.M., Marzetti, L., de Pasquale, F., Di Pompeo, F., Stout, J., Woolrich, M., Luo, Q., Bucholz, R., Fries, P., Pizzella, V., Romani, G.L., Corbetta, M., Snyder, A.Z. (2013) Adding dynamics to the Human Connectome Project with MEG. Neuroimage. 80:190-201 PMID 23702419
Larson-Prior, L.J., Ju, Y-E.S., Galvin, J.E. Cortical-subcortical interactions in hypersomnia disorders: mechanisms underlying cognitive and behavioral aspects of the sleep-wake cycle. Front Neurol, in press